Improving Carcinogenicity Assessment

Carcinogenicity Assessment of Titanium Dioxide

Introduction Titanium dioxide is a white mineral that is used to color paints, plastics, paper and other materials and is approved by the FDA as both a direct (with restricted uses) and indirect food additive. It is a non-genotoxic poorly soluble particulate. As such it has been found to not cause cancer by various routes in a number of animal models except for the rat. Titanium dioxide, as wit...

Assessment of the Carcinogenicity of Formaldehyde

Respiratory carcinogenicity assessment of soluble nickel compounds.

The many chemical forms of nickel differ in physicochemical properties and biological effects. Health assessments for each main category of nickel species are needed. The carcinogenicity assessment of water-soluble nickel compounds has proven particularly difficult. Epidemiologic evidence indicates an association between inhalation exposures to nickel refinery dust containing soluble nickel com...

EFSA explains the carcinogenicity assessment of glyphosate

During the EFSA peer-review process for the renewal of the approval of the pesticide active substance glyphosate, EFSA received a complementary mandate from the European Commission to consider the findings by the International Agency for Research on Cancer (IARC) regarding the potential carcinogenicity of glyphosate or glyphosate containing plant protection products. Following the request, EFSA...

Risk assessment of nickel carcinogenicity and occupational lung cancer.

Recent progress in risk assessment of nickel carcinogenicity and its correlation with occupational lung cancer in nickel-exposed workers is reviewed. Epidemiological investigations provide reliable data indicating the close relation between nickel exposure and high lung cancer risk, especially in nickel refineries. The nickel species-specific effects and the dose-response relationship between n...